Journal of Medicinal Chemistry
Volume 40, Issue 12 (June 6, 1997)
Copyright © 1997 American Chemical Society

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1763-1767

Novel Conformationally Extended Naphthalene-Based Inhibitors of Farnesyltransferase Christopher J. Burns, Jean-Dominique Guitton, Bernard Baudoin, Yves Lelièvre, Marc Duchesne, Fabienne Parker, Nadine Fromage, and Alain Commerçon [Full Article - PDF]

1768-1770

9-Benzyladenines: Potent and Selective cAMP Phosphodiesterase Inhibitors Jean-Jacques Bourguignon, Laurent Désaubry, Pierre Raboisson, Camille-Georges Wermuth, and Claire Lugnier [Full Article - PDF]

1771-1772

Substituted [(4-Phenylpiperazinyl)- methyl]benzamides: Selective Dopamine D4 Agonists Shelly A. Glase, Hyacinth C. Akunne, Lynn M. Georgic, Thomas G. Heffner, Robert G. MacKenzie, Peter J. Manley, Thomas A. Pugsley, and Lawrence D. Wise [Full Article - PDF]

1773-1778

Synthesis and Biological Evaluation of the Enantiomers of the Potent and Selective A1-Adenosine Antagonist 1,3-Dipropyl-8-[2-(5,6-epoxynorbonyl)]- xanthine Jürg R. Pfister, Luiz Belardinelli, Gavin Lee, Robert T. Lum, Peter Milner, William C. Stanley, Joel Linden, Stephen P. Baker, and George Schreiner [Full Article - PDF]

1779-1788

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists Benny C. Askew, Rodney A. Bednar, Bohumil Bednar, David A. Claremon, Jacquelynn J. Cook, Charles J. McIntyre, Cecila A. Hunt, Robert J. Gould, Robert J. Lynch, Joseph J. Lynch, Jr., Stanley L. Gaul, Maria T. Stranieri, Gary R. Sitko, Marie A. Holahan, Joan D. Glass, Terrence Hamill, Lynn M. Gorham, Thomayant Prueksaritanont, John J. Baldwin, and George D. Hartman [Full Article - PDF]

1789-1793

Address and Message Sequences for the Nociceptin Receptor: A Structure-Activity Study of Nociceptin-(1-13)-peptide amide Remo Guerrini, Girolamo Calo', Anna Rizzi, Clementina Bianchi, Lawrence H. Lazarus, Severo Salvadori, Piero A. Temussi, and Domenico Regoli [Full Article - PDF]

1794-1807

Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework Giuseppe A. M. Giardina, Henry M. Sarau, Carlo Farina, Andrew D. Medhurst, Mario Grugni, Luca F. Raveglia, Dulcie B. Schmidt, Roberto Rigolio, Mark Luttmann, Vittorio Vecchietti, and Douglas W. P. Hay [Full Article - PDF]

1808-1819

Novel and Selective Partial Agonists of 5-HT3 Receptors. 2. Synthesis and Biological Evaluation of Piperazinopyridopyrrolopyrazines, Piperazinopyrroloquinoxalines, and Piperazinopyridopyrroloquinoxalines Hervé Prunier, Sylvain Rault, Jean-Charles Lancelot, Max Robba, Pierre Renard, Philippe Delagrange, Bruno Pfeiffer, Daniel-Henri Caignard, René Misslin, Béatrice Guardiola-Lemaitre, and Michel Hamon [Full Article - PDF]

1820-1826

Tyrosine Kinase Inhibitors. 12. Synthesis and Structure-Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor Gordon W. Rewcastle, Alexander J. Bridges, David W. Fry, J. Ronald Rubin, and William A. Denny [Full Article - PDF]

1827-1834

Structure-Cytoprotective Activity Relationship of Simple Molecules Containing an ,-Unsaturated Carbonyl System Ana M. Rodríguez, Ricardo D. Enriz, Luis N. Santagata, Esteban A. Jáuregui, Mauricio J. Pestchanker, and Oscar S. Giordano [Full Article - PDF]

1835-1844

A Technetium-99m SPECT Imaging Agent Which Targets the Dopamine Transporter in Primate Brain Peter C. Meltzer, Paul Blundell, Alun G. Jones, Ashfaq Mahmood, Basem Garada, Robert E. Zimmerman, Alan Davison, B. Leonard Holman, and Bertha K. Madras [Full Article - PDF]

1845-1854

Synthesis and Anti-HIV Activity of Novel N-1 Side Chain-Modified Analogs of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) Renée Pontikis, Rachid Benhida, Anne-Marie Aubertin, David S. Grierson, and Claude Monneret [Full Article - PDF]

1855-1862

Simulation of Protein-Sugar Interactions: A Computational Model of the Complex between Ganglioside GM1 and the Heat-Labile Enterotoxin of Escherichia coli Anna Bernardi, Laura Raimondi, and Fabio Zuccotto [Full Article - PDF]

1863-1869

Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives Masami Kaneko, Yutaka Saito, Hiromitsu Saito, Tadashi Matsumoto, Yuzuru Matsuda, Jeffry L. Vaught, Craig A. Dionne, Thelma S. Angeles, Marcie A. Glicksman, Nicola T. Neff, David P. Rotella, James C. Kauer, John P. Mallamo, Robert L. Hudkins, and Chikara Murakata [Full Article - PDF]

1870-1875

Novel Prodrugs of Cyanamide That Inhibit Aldehyde Dehydrogenase in Vivo Frances N. Shirota, Janell M. Stevens-Johnk, Eugene G. DeMaster, and Herbert T. Nagasawa [Full Article - PDF]

1876-1885

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase Philip D. Edwards, Donald W. Andisik, Craig A. Bryant, Barbara Ewing, Bruce Gomes, Joseph J. Lewis, Donna Rakiewicz, Gary Steelman, Ann Strimpler, Diane A. Trainor, Paul A. Tuthill, Russell C. Mauger, Chris A. Veale, Richard A. Wildonger, Joseph C. Williams, Donald J. Wolanin, and Mark Zottola [Full Article - PDF]

1886-1893

Structural Studies on Bioactive Compounds. 28. Selective Activity of Triazenyl-Substituted Pyrimethamine Derivatives against Pneumocystis carinii Dihydrofolate Reductase Malcolm F. G. Stevens, Keith S. Phillip, Daniel L. Rathbone, Dennis M. O'Shea, Sherry F. Queener, Carl H. Schwalbe, and Peter A. Lambert [Full Article - PDF]

1894-1900

Design and Synthesis of Potent Antitumor 5,4'-Diaminoflavone Derivatives Based on Metabolic Considerations Tsutomu Akama, Hiroyuki Ishida, Yasushi Shida, Uichiro Kimura, Katsushige Gomi, Hiromitsu Saito, Eiichi Fuse, Satoshi Kobayashi, Nobuyuki Yoda, and Masaji Kasai [Full Article - PDF]

1901-1905

Substituted N-Phenylisothioureas: Potent Inhibitors of Human Nitric Oxide Synthase with Neuronal Isoform Selectivity Barry G. Shearer, Shuliang Lee, Jeffrey A. Oplinger, Lloyd W. Frick, Edward P. Garvey, and Eric S. Furfine [Full Article - PDF]

1906-1918

Dual Inhibition of Human Leukocyte Elastase and Lipid Peroxidation: In Vitro and in Vivo Activities of Azabicyclo[2.2.2]octane and Perhydroindole Derivatives Bernard Portevin, Michel Lonchampt, Emmanuel Canet, and Guillaume De Nanteuil [Full Article - PDF]

1919-1929

Structure-Activity Relationships for Acridine-Substituted Analogues of the Mixed Topoisomerase I/II Inhibitor N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide Julie A. Spicer, Swarna A. Gamage, Graham J. Atwell, Graeme J. Finlay, Bruce C. Baguley, and William A. Denny [Full Article - PDF]

1930-1936

Synthesis and Biological Activities of Conformationally Restricted, Tricyclic Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductases Aleem Gangjee, Jufang Shi, and Sherry F. Queener [Full Article - PDF]

1937-1939

Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 3. Synthesis and Antimalarial Activity in Vitro and in Vivo of the New Gold-Chloroquine Complex [Au(PPh3)(CQ)]PF6 Maribel Navarro, Hilda Pérez, and Roberto A. Sánchez-Delgado [Full Article - PDF]

1940-1940

Comprehensive Organic Functional Group Transformations Edited by A. R. Katritzky, O. Meth-Cohn, and C. W. Rees. Pergamon Press (Elsevier Science Ltd.), Tarrytown, NY. 1995. 7 vols., 19.5 × 28 cm. vol. 1, xix + 1420 pp; vol. 2, xix + 1441 pp; vol. 3, xix + 941 pp; vol. 4, xix + 1352 pp; vol. 5, xix + 1442 pp; vol. 6, xix + 933 pp; vol. 7, xvii + 1251 pp. ISBN 0-08-042-322-1; 0-08-042-323-X; 0-08-042-324-8; 0-08-0442-325-6; 0-08-042-326-4; 0-08-042-704-9; 0-08-042-705-7. $4310 (set). Joseph G. Cannon [Full Article - PDF]